About Us

Peer Reviewed Articles

Multiorgan Culture Devices for Real-Time Metabolite and Toxicity Screening

  • Lubamba, G., Jensen, T., McClelland, R. “Rapid detection of direct compound toxicity and trailing detection of indirect cell metabolite toxicity in a 96-well fluidic culture device for cell-based screening environments: tactics in six-sigma quality control charts”. MDPI Applied Science (Volume 12(6), pg 2786). Online doi.org/10.3390/app12062786. 2022.
  • John, B., Sloan, D., Jensen, T., Ramaiahgari, S., End, P., Resh, G., McClelland, R. “A unidirectional 96-well fluidic culture platform for upstream cell dosing with subsequent downstream nonlinear and ascending exposure gradients for real-time and cell-based screening environments”.  Applied In Vitro Toxicology (Volume 7, pg 175-191). Online doi.org/10.1089/aivt.2021.0006. 2021.

Assay Development

  • Tikunov, A.P., Winnike, J.H., Tech, K., Jeffries, R.E., Semelka, C., Martin, J., McClelland, R., Graves, L.M., Macdonald, J.M. “Fluxomics by NMR Spectroscopy from Cells to Organisms Focusing on Liver”.  Current Metabolomics (Volume 1, pg 128-159) 2013.
  • Winnike, J.H., Pediaditakis, P., Wolak, J.E., McClelland, R.E., Watkins, P.B., Macdonald, J.F. “Stable Isotope Resolved Metabolomics of Primary Human Hepatocytes Reveals a Stressed Phenotype”.  Metabolomics (Volume 8, No. 1, pg 34-49) 2012.
  • Seagle, C., Christie, M., Winnike, J., McClelland, R., Ludlow, W., O’Connell, T., MacDonald, J. “High Through-put NMR Metabolomic Footprinting for Tissue Engineering”.  Tissue Engineering, Part C (Volume 14, Ver. 2, pg 97-105) 2008.

Device Development

  • McClelland R.E. and Coger R.N.  “Effects of Enhanced O2 Transport on Hepatocytes Packed within a Bioartificial Liver Device”.  Tissue Engineering (Volume 10, Number 1/ 2, pg 253-266) 2004.
  • McClelland R.E., MacDonald J., and Coger R.N.  “Modeling 02 Transport within Engineered Hepatic Bioartificial Devices”.  Journal of Biotechnology and Bioengineering (Volume 82, Issue 1, pg 12-27) 2003.
  • McClelland R.E. and Coger R.N.  “Use of Micropathways to Improve Oxygen Transport in a Hepatic System”.  Journal of Biomechanical Engineering, Vol. 122, no. 3 pp. 268-273) 2000.

Book Chapters

  • McClelland, R., Tech, K., Macdonald, J. “Construction of a Multicoaxial Hollow Fiber Bioreactor”.  In: Organ Rengeneration: Methods and Protocols, Methods in Molecular Biology.  Vol. 1001, DOI10.1007/978-1-62703-363-3_19.  Accepted Feb. 2013.
  • Tikunov, A., Winnike, JH., Tech, K., Jeffies, RE., Semelka, C., McClelland, R., Graves. LM., Macdonald, JM. “Fluxomics by NMR Spectroscopy from Cells to Organs”.  Current Metabolomics.  (accepted 2012).
  • McClelland R., et.al.  “Tissue Engineering”.  Introduction to Biomedical Engineering. (J. Enderle, S. Blanchard, J. Bronzino, editors).  Elsevier: Chapter 7, pg 313-400 (2005).